Research

Research Program

Summary

Our research program addresses fundamental questions on the regulation and mechanism of action of ncRNAs, their roles in development and their disease relevance:

1) How are ncRNA biogenesis and transport controlled in CV cells?

2) Through which mechanisms do ncRNA control CV signaling and infer with e.g. epigenetic control, transcription and mRNA processing?

3) How do ncRNAs govern disease processes and regeneration, and can this be exploited by manipulating their expression or activity?

These questions will be addressed by combining outstanding and complementary expertise in a collaborative manner, making use of an excellent infrastructure and state-of-the art technology at our sites, and by educating young scientists in an interdisciplinary environment.

Research Focus Areas

Our research includes two main research focus areas aiming at new targets for therapy development. They are complemented by infrastructural projects.

Projects

Project section A assembles projects that analyse the regulation and mechanism of action of non-coding RNAs. Section B of the subprojects bundles projects that aim to decipher the role of ncRNAs in CV development, disease and regeneration. The infrastructure is ensured by three central projects providing “omics-“ and bioinformatic platforms as well as coordinative and administrative support (section Z).

Finished projects

List of closed projects from the 1st funding period.

See more

Project Z01

Central administration

Project Leader
Prof. Dr. Dr. Stefan Engelhardt & Prof. Dr. Stefanie Dimmeler

Team
Dorothea Marquardt, Claudia Herfuhrt, Dr. Sebastian Cremer

The central office of the CRC will manage all administrative and organizational tasks related to this research centre. Z01 (Stefan Engelhardt & Stefanie Dimmeler) will be a permanent contact for all scientists, providing them with guidance in requesting and handling of funds, the organization of meetings and conferences, access to career support programs and measures that facilitate the compatibility of family life and career. It will supervise the implementation and success of these activities and encourage those to participate who are in need.

As a hub for PhD students, project Z01 will ensure smooth and unbureaucratic access to existing and planned training activities such as workshops, lab visits and student exchange programs in the CRC. For a broader scientific audience in the field (i.e. also addressing undergraduate or post-PhD scientists), project Z01 will organise meetings, seminars and conferences with invited speakers. All scientists in this CRC who seek collaboration with platform technology labs (Z02, Z03) will receive administrative support, e.g. how costs for Z02 service are charged and how legal issues of data exchange between institutions are managed.

The outreach via website or press releases is another task taken over by Z01, since this will raise recognition by other scientists and may initiate fruitful scientific collaborations or future recruitments. Not least, we will inform the general public about our activities through this website and other media, thereby raising the awareness for cardiovascular diseases and our research.